Clinique Clinical Trials

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Acne – American Academy of Dermatology Promotes Alternatives to Antibiotics

 

 

 

 

While the spotlight has recently been on revolutionary acne treatments such as laser and light-based therapies, there have been huge advances in oral medications used to treat acne. Many dermatologists believe that oral medications still offer the best long term results for acne sufferers, but traditional antibiotics have many drawbacks in that they need to be taken on an empty stomach, they can cause yeast infections, and long term use can lead to bacterial resistance.

 

This article will outline a few of the alternative oral medications that were discussed at the American Academy of Dermatology´s Summer Academy Meeting in 2007.

 

- Extended-release minocycline to treat acne

 

Immediate-release minocycline has previously been used to treat acne, but the peak serum levels in the blood that it can cause often lead to side effects such as dizziness, headaches and nausea. Using extended-release minocycline reduces the peak serum levels, reducing these potential side effects. This oral medication is taken once per day and can be taken on a full or empty stomach making it a convenient alternative to medications that need to be taken a certain time before meals.

 

- Using a ‘step down’ approach with antibiotics and a topical retinoid

 

To combat the issue of bacterial resistance from long term antibiotic use, dermatologists are recommending a ‘step down’ approach to acne therapy. This means taking an oral antibiotic in conjunction with a topical retinoid for a short period of time to kick start the treatment, and then stopping the antibiotic and continuing using just the topical retinoid. This process has had excellent results, and clinical studies have shown that in most cases acne continues to improve after the antibiotic course has been discontinued.

 

- Using anti-inflammatory medications to treat acne

 

Dermatologists have discovered that anti-inflammatory oral medications can be very effective at decreasing the severity of acne. A new anti-inflammatory medication that has been FDA approved for the treatment of acne rosacea is controlled-release doxycycline, which works by reducing the swelling and redness associated with acne.

 

Anti-inflammatory drugs will not actually get rid of acne as the bacteria that causes the spot is not destroyed or removed. However, those people who find that antibiotic treatments can cause the onset of yeast infections, may prefer to use anti-inflammatory medications that can provide a significant improvement in the appearance of their acne.

 

- Early signs that incyclinide could help to treat acne

 

In the next few years it is expected that incyclinide could be added to the menu of oral medications used to treat acne and acne rosacea. A modified tetracycline, it is currently in its second phase of clinical trials and it looks likely that it will provide another effective alternative to antibiotic treatments.

 

- Consult a dermatologist to determine the best oral medication for you

 

With an ever expanding range of medications available to treat acne, it is crucial that you consult a dermatologist at the earliest opportunity to determine the most appropriate course of treatment for your particular condition. Oral medications used to treat acne do not work instantly, and it may be six to eight weeks before you start to see any improvement at all. With a little patience and careful adherence to your dermatologist’s instructions, many cases of acne can be effectively treated with oral medications.

 

 

 

 

 

 

 

 

 

 

 

 

 

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About the Author

Jimmy Low, sgtopmarketseller@gmail.com, Freelance SelfEmployed Graduate

Global Clinical Trials (Hardcover) $224.61 This title explores the great opportunities and challenges which exist in conducting clinical trials in developing countries. –

Clinical Trials in Neurology (Hardcover) $198.79 "Translating laboratory discoveries into successful therapeutics can be difficult. Clinical Trials in Neurology aims to improve the efficiency of clinical trials and the development of interventions in order to enhance the development of new treatments for neurologic diseases. It introduces the reader to the key concepts underpinning trials in the neurosciences. This volume tackles the challenges of developing therapies for neurologic disorders from measurement of agents in the nervous system to the progression of clinical signs and symptoms through illustrating specific study designs and their applications to different therapeutic areas. Clinical Trials in Neurology covers key issues in Phase I, II and III clinical trials, as well as post-marketing safety surveillance. Topics addressed include regulatory and implementation issues, outcome measures and common problems in drug development. Written by a multidisciplinary team, this comprehensive guide is essential reading for neurologists, psychiatrists, neurosurgeons, neuroscientists, statisticians and clinical researchers in the pharmaceutical industry"–

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Strategy and Statistics in Clinical Trials (Paperback) $140.3 Strategy and Statistics in Clinical Trials is for all individuals engaged in clinical research, including professors, physicians, researchers in corporate and government laboratories, nurses, members of the allied health professions, and post-doctoral and graduate students who are potentially less exposed to understanding the pivotal role of statistics.? Enables nonstatisticians to better understand research processes and statistics` role in these processes ? Offers real-life case studies and provides a practical, "how to" guide to biomedical R&D ? Delineates the statistical building blocks and concepts of clinical trials ? Promotes effective cooperation between statisticians and important other parties

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Design, Execution, and Management of Medical Device Clinical Trials (Hardcover) $160.68 Design, Execution, and Management of Medical Device Clinical Trials Salah m. Abdel-Aleem An essential introduction to conducting the various stages of medical device clinical trials Clinical research continues to be one of the most vital components of pharmaceutical, biostatistical, and medical studies. Design, Execution, and Management of Medical Device Clinical Trials provides a uniform methodology for conducting and managing clinical trials. Written in a style that is accessible to readers from diverse educational and professional backgrounds, this book provides an in-depth and broad overview for successfully performing clinical tasks and activities. Throughout the book, practical examples compiled from both the author`s and other researchers` previous clinical trial experiences are discussed in a sequential manner as they occur in the study, starting from the development of the clinical protocol and the selection of clinical sites and ending with the completion of the final clinical study report. Next, readers are guided through the development of important clinical documents, including informed consent forms, case report forms, and study logs. A careful review of the Food and Drug Administration (FDA) and International Conference on Harmonisation (ICH) regulations applicable to medical devices is also featured. Additional coverage includes: Qualification and selection of investigators Study monitoring visits Definitions and reporting procedures for adverse events The use of biostatistical methodology in clinical research, including the use of biostatistics for sample size determination and study endpoints The roles and responsibilities of all members of a clinical research team The book concludes with an insightful discussion of special ethical conduct for human research and challenging issues to consider during the design of clinical studies. A glossar

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